Identification of inflammatory gene modules based on variations
of human endothelial cell responses to oxidized lipids
Method: Weighted Gene Co-Expression Network Analysis ( WGCNA )
Weighted Gene Coexpression Network Analysis
Peter S. Gargalovic, Minori Imura, Bin Zhang, Nima M. Gharavi, Michael J. Clark, Joanne Pagnon, Wen-Pin Yang, Aiqing He, Amy Truong, Shilpa Patel , Stanley F. Nelson , Steve Horvath, Judith A. Berliner, Todd G. Kirchgessner, and Aldons J. Lusis (2006) Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids. Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12741-6
Link to PNAS Paper Webpage: Here
Link to PNAS Paper PDF file: Here
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Other material regarding weighted gene co-expression network analysis
Weighted Gene Co-Expression Network Page
The weighted gene co-expression network analysis method is described in Theory Paper 1: Zhang and Horvath (2005)
For a more mathematical description of weighted gene co-expression networks consider Theory Papers: Dong and Horvath (2007, 2008)